Genetic incidental findings: autonomy regained?
نویسندگان
چکیده
منابع مشابه
Point-counterpoint. Patient autonomy and incidental findings in clinical genomics.
1049 POLICYFORUM E xome and whole-genome sequenc-ing are rapidly moving into clinical application to aid diagnosis and treatment. However, a startling statement by the American College of Medical Genetics and Genomics (ACMG) may prove to be a stumbling block (1). Rather than reconfi rming well-established principles of patient autonomy and informed consent that have long applied in medical gene...
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The rapidly declining costs and increasing speeds of whole-genome analysis mean that genetic testing is undergoing a shift from targeted approaches to broader ones that look at the entire genome. As whole-genome technologies gain widespread use, questions about the management of so-called incidental findings-those unrelated to the question being asked-need urgent consideration. In this review, ...
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Nowhere are the ethical issues in genomic research more complex than in pediatrics. Balancing the sometime conflicting autonomy of the parent and the child, and the best interest of the family and the child, brings up many challenging issues. Addressing this balance, especially in the context of the child's developing maturity and comprehension, requires deep analysis and discussion. Issues dis...
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The Human Genome Project showed that there is significant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental findings create legal, ethical, and financial challenges for researchers. Current federal and internationa...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2013
ISSN: 1098-3600,1530-0366
DOI: 10.1038/gim.2013.104